I am living with a mild form of Alzheimers

Welcome to the "club". I was diagnoised with Mild Cognitive Impairment (MCI) in the spring of 2024, and I started on Leqembi in June 2024. I recently had my 33rd infusion. I had a repeat quick cognitive test about a year after starting on Leqembi (Montreal Cognive Assessment, or MoCA), and I scored the same. I take that as a good sign.

LIke you, I can readily answer general questions posed to me. To the casual observer, it does not appear that I have Alzheimer's. Of course, if they told me a short story about a recent event that occurred in their lives, then we discussed other topics, and later they asked me pointed questions about details from their short story, then I wouldn't be able to respond very well. But this loss of short-term memory isn't apparent to the casual observer.

So, life goes on. I'm hopeful that Leqembi will help me maintain enough cognition over the next few years until more powerful drugs become available. An example of a more powerful drug would be the clinical trial pairing Leqembi with Etalanetug (an anti-tau drug, whereas Leqembi is an anti-amyloid drug).

My favorite story about Leqembi involves Ralph Carmona. He was a participant in an early clinical trial with Leqembi about 10 years ago. He ran in the Boston Marathon in 2025, with a time of 4H14M42S, after visiting 5 medical tents along the way due to cramps. Clearly, not everybody on Leqembi will compete in the Boston Marathon. But still, who would have thought that after 10 years on Leqembi, somebody diagnoised with AD would be competing in the Boston Marathon!