could it be a breakthrough????

GMGYPSY

     I am currently half way through The Code Breakers by Walter Isaacson. .  It is  about DNA and RNA  and gene editing.  Its  also about the  science that has led to the vaccine being used  to fight covid 19. It's a very interesting book  and they have only mentioned  Alzheimmers twice  so far . Still if they can edit the genes maybe this could be very beneficial in dementia research.   It's just a thought.

Crushed

DD#1 did her PhD in editing genes.  The trick is not editing. It is Knowing what the sequences do

GMGYPSY

Tell me more crushed.    BTW I do know there are a lot of ethical questions  that make this a controversy.   Just thought it's an interesting  topic

Crushed

The components of DNA are

" adenine (A), thymine (T), guanine (G) and cytosine (C). The order, or sequence, of these bases determines what biological instructions are contained in a strand of DNA. For example, the sequence ATCGTT might instruct for blue eyes, while ATCGCT might instruct for brown.

The complete DNA instruction book, or genome, for a human contains about 3 billion bases and about 20,000 genes on 23 pairs of chromosomes."

Gene encode proteins, it the proteins that actually do the work

So you have to work backwards from the proteins

Two proteins are relevant to Alzheimer's Amyloid  Beta and Tau

But we don't know how they related to disease causation

"These mechanisms, their interactions, and their potential for pharmacological modulation, are partially understood at best. " 

Thsi article shows just how complicated the search for some kind of really is.  

https://www.nature.com/articles/s41598-021-82658-7

GMGYPSY

  Thank you Crushed  that was very helpful  I can see that we have a very long way to go.  I have faith that science will eventually figure it out , sadly not in time for my DHbut maybe  for my grandchildren or  great grandchildren. Let's hope.