Peroxynitrite scavenging product

Lane Simonian

I am not endorsing this product and I don't know how effective it would be against Alzheimer's disease.  Almost all of the ingredients are peroxynitrite scavengers and the company's explanation of the problems created by peroxynitrite is spot on.

Ingredients:

• Vitamin B2
• Vitamin B12
• Calcium
• Garlic extract
• Exhinacea root powder
• Rosemary powder
• Witch Hazel leaf powder
• Larch tree fiber    
•  
• Description:
  Peroxynitrite Scavenger is designed to help clear the body of the dangerous free radical, peroxynitrite. Peroxynitrite is considered to be one of the major pathological causes of numerous diseases because it suppresses mitochondrial function and triggers cell death via oxidation and nitration reactions. Poor diets, environmental toxins, and genetic variants can all lead to an increase in peroxynitrites and glutamate, lowered antioxidants and slower rebuilding and repair of cells, which causes faster aging and conditions for disease. This product can be used for those genetically at risk for high levels of inflammation and/or those with signs and symptoms of inflammation.
  Nitric Oxide, NO, a natural signaling molecule, is highly reactive with superoxide and produces peroxynitrite, a power oxidant; as a reaction unmediated by an enzyme, peroxynitrite is produced nearly instantaneous upon collision between molecules. Through interaction with DNA, proteins and lipids, peroxynitrite mediates cellular function in variety of ways, ranging from minor changes to cellular communication to apoptosis. Acting as a catalyst, peroxynitrite’s oxidant properties can be observed through nos uncoupling, the process of BH4 being catalyzed, releasing superoxide. As a cofactor for peroxynitrite, superoxide production may pose negative health implications. During in vivo research, peroxynitrite has been shown to be factor in conditions such as a stroke, chronic heart failure, myocardial infarction, circulatory shock, chronic inflammatory diseases, diabetes, and neurodegenerative disorders; furthermore, peroxynitrite has been associated with carcinogenesis, and aging. It has been reported that even moderate instability in peroxynitrite has the ability to disrupt cellular processes, signaling, and induce cell death. Mitochondrial function, which produces both NO and superoxide, is also drastically effected by peroxynitrite; it is suggested peroxynitrite may influence nearly every function of the mitochondria.

 

Crushed

The Food, Drug, and Cosmetic Act defines “drug” as any article (except devices) “intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease” and “articles (other than food) intended to affect the structure or function of the body.” These words permit the FDA to stop the marketing of products with unsubstantiated “drug” claims on their labels.

To evade the law’s intent, the supplement industry is organized to ensure that the public learns of “medicinal” uses that are not stated on product labels. This is done mainly by promoting the ingredients of the products through books, magazines, newsletters, booklets, lectures, radio and television broadcasts, oral claims made by retailers, and the Internet.

DSHEA worsened this situation by increasing the amount of misinformation that can be directly transmitted to prospective customers. It also expanded the types of products that could be marketed as “supplements.” The most logical definition of “dietary supplement” would be something that supplies one or more essential nutrients missing from the diet. DSHEA went far beyond this to include vitamins; minerals; herbs or other botanicals; amino acids; other dietary substances to supplement the diet by increasing dietary intake; and any concentrate, metabolite, constituent, extract, or combination of any such ingredients. Although many such products (particularly herbs) are marketed for their alleged preventive or therapeutic effects, the 1994 law has made it difficult or impossible for the FDA to regulate them as drugs. Since its passage, even hormones, such as DHEA and melatonin, are being hawked as supplements.
https://quackwatch.org/consumer-protection/dshea/

it's Quack heaven folks they can say anything they want

 
 

  

Lane Simonian

The two most dangerous ideas in medicine: any herbal supplement can be used to treat any medical condition; no herbal supplement can ever be used to treat any medical condition.

Here is a little more information about how this supplement is sold.

Are you a patient?

We only sell our products to licensed healthcare practitioners. If you are a patient and are interested in our products, please speak with your doctor or pharmacist.

Crushed

That is the quackery pure and simple
 
 

Are you a patient?

 

We only sell our products to licensed healthcare practitioners. If you are a patient and are interested in our products, please speak with your doctor or pharmacist.

Doctors and pharmacists use drugs  “drug” as any article (except devices) “intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease”

If its not a drug why do you need a doctor or pharmacist ?   They want you to THINK its a drug without the proof required for a drug

Quack quack quack quack quack

A herbal supplement promoted for a medical condition is a DRUG 

 

Lane Simonian

Yes, the compounds in herbal supplements act as drugs--in this case as peroxynitrite scavengers.  If you find the compounds which do this the best, you potentially can treat a whole variety of poorly treated or untreated disease.  But because herbs are not perceived as drugs but as quack medicines, they are not given any credibility.  They are just like any other drug, though: some are effective and some are not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248324/

Crushed

Lane Simonian wrote:

Yes, the compounds in herbal supplements act as drugs--in this case as peroxynitrite scavengers.  If you find the compounds which do this the best, you potentially can treat a whole variety of poorly treated or untreated disease.  But because herbs are not perceived as drugs but as quack medicines, they are not given any credibility.  They are just like any other drug, though: some are effective and some are not.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248324/

Not the issue and not what I said. A substance is a drug  because it is PROMOTED as a drug

The FDA is concerned with garbage promoted as a drug,  If you "find" something works you publish  the findings for review and submit the product   as  a drug.

 
 

Larrytherunner

These herbal supplement marketers could always sponsor their products for FDA clinical trials but they never do. Rather they come up with their own so-called clinical trials where they can make up their own results and use it for advertising. Then they make lots of money and it takes years for the government to stop them. For them going to court is just a cost of doing business.

Lane, these articles you are referring to are generalizations about peroxynitrite. You keep making assumptions for promoting products that the articles that you are pointing to don't back up. Marketers make all kinds of assumptions based on manipulating words but real scientists use laboratory results and a real knowledge of science to back it up.

Lane Simonian

There is an aspect of truth in this, although it is often used to throw the baby out with the bath water.

The damage done by peroxynitrite to the brain in Alzheimer's disease is very specific.  It includes oxidation and nitration which disables receptors, transport systems, and enzymes involved in maintaining levels of neurotransmitters needed for the retrieval of short-term memory, sleep, balanced mood, alertness, and social recognition, for the regeneration of neurons, for maintaining blood flow, and for cell survival.  Witch hazel and rosemary are very good peroxynitrite scavengers.  The one ingredient in the supplement that is not a peroxynitrite scavenger is calcium which may be a concern as calcium release and influx are problem in Alzheimer's disease.

Not by chance all the natural products and drugs that have shown promise in the treatment of Alzheimer's disease are peroxynitrite scavengers.  These include Anavex 2-73, GV-971, TrappsolCyclo, and panax ginseng.  Others such as montelukast slow down the production of peroxynitrite and therefore may slow down the progression of the disease.

Crushed

There are first class researchers all over the world looking at Alzheimers.  There is a Nobel prize for anyone anywhere who can actually PROVE what you ASSERT so confidently.  That is why we actually do the research, to separate reality from nonsense.  Snake oil salesmen have bee n around for centuries

Lane Simonian

This is not my original hypothesis; it is backed by some of the best Alzheimer's researchers in the field.

Stuck in the middle

The best researchers in the world don't even know the cause of AD.  They have some ideas, but are willing to admit that they can't prove them.  Just as one example, there is major argument as to whether amyloid plaque is the killer or the tombstone; does it cause disease, or is it created by the brain in an attempt to protect itself, like an oyster making a pearl to cover the irritation caused by a grain of sand?

Lane Simonian

We now know most of the answers regarding amyloid.  There was no correlation between the removal of amyloid plaques and cognition at the highest dose in aducanumab trial and only a weak correlation at the lowest dose.  There is no impact of the removal of amyloid oligomers on cognition in non-ApoE4 carriers and only a slight slowing in the progression of the disease after the removal of amyloid oligomers in ApoE4 carriers.  So thirty years of focusing on amyloid as the cause of Alzheimer's disease was basically wasted.

I have been studying Alzheimer's for nearly twenty years, and we know much more about the disease now than most people realize.

Lane Simonian

This recent study gets us a little closer to the heart of Alzheimer's disease:

Notably, Aβ aggregates induce the neuronal ONOO- [peroxynitrite] generation, which conversely facilitates Aβ aggregation. The two critical events, ONOO- stress and Aβ aggregation, mutually amplify each other through positive feedback mechanisms and jointly promote the AD onset and progression. Furthermore, by coimaging of the level dynamics of Aβ plaques and ONOO-, we found that the cerebral ONOO- is a potential biomarker, which emerges earlier than Aβ plaques in transgenic mouse models.

Peroxynitrite which damages enzymes, receptors, and transport systems in the brain that are necessary for the retrieval of short-term memory and for the regeneration and survival of neurons, also plays a role in the formation of amyloid oligomers and plaques, the former which then for awhile contributes to the further production of peroxynitrite.  If Alzheimer's researchers had paid as much attention to preventing the formation and removal of peroxynitrite as they did to preventing the formation and removal of amyloid we would be much closer to a treatment for Alzheimer's disease than we currently are.

Paris20

To the O/P, please don’t offer unverified promises to people who know all too well what Alzheimer’s disease does to people. Most of us on these boards have read as much as we can about this awful, terminal illness. We try to get through each day, knowing that the worst is happening. To throw invalid stuff at us is hurtful, not helpful. If your “information” were in any way a breakthrough for patients, at least some of our neurologists would have heard about it. With all the dead ends that hard-working, well-qualified researchers have hit, I simply cannot accept or believe unproven wishes and dreams based on illogical leaps from one tidbit of information to spurious conclusions. We have enough to deal with already.

Lane Simonian

All I ask is that people look at the trial results using peroxynitrite scavengers such as GV-971, panax/Korean red ginseng, and Anavex 2-73 (blarcamesine).   People have dug their heals so hard into the ground regarding treatments for Alzheimer's disease that they cannot see the sky. 

Marta

Scientific method:  

1. Make an observation that describes a problem. 

2.  Create a hypothesis. 

3.  TEST the hypothesis.  Picking and choosing among the literature is NOT testing the hypothesis. 

4. Draw conclusions and refine the hypothesis. Submit to a peer reviewed publication. 

Lane. You have been stuck at step 2 for many years now. 

Long past time to proceed to step 3.  If you get beyond 4, come here and tell us about it. 

Lane Simonian

Others have already done steps 3 and 4 for me.

The cost of doing a clinical trial, and the prospects of attaining funds for such a trial are daunting to say the least.