More bad news on Aduhelm

Crushed

https://www.nytimes.com/2021/11/22/health/aduhelm-death-safety.html

Concerns Grow Over Safety of Aduhelm After Death of Patient Who Got the Drug

Newly published safety data shows that 41 percent of patients in key clinical trials of the Alzheimer’s drug experienced brain bleeding or swelling, though many cases were asymptomatic.......

Brain swelling and brain bleeding are known to be possible side effects of Aduhelm, a monoclonal antibody that is administered as a monthly infusion. The F.D.A. approved the drug in June even though a council of senior F.D.A. officials, an advisory committee of outside experts, and many Alzheimer’s specialists said it was unclear whether Aduhelm could benefit patients and that the drug carried serious risks of harm......

Dr. Sam Gandy, an Alzheimer’s clinician who is director of the Mount Sinai Center for Cognitive Health, said that another major concern is that the patients in the Aduhelm clinical trials were healthier than many people with Alzheimer’s who might use the drug now that it is available. People were excluded from participating in the trials if they had medical issues that many older people experience, including previous cardiac problems, any indication of impaired liver or kidney function or if they were taking blood thinners.

The F.D.A. label does not exclude any of these conditions. “Now if those common comorbidities are not excluded and it’s sort of all comers,” Dr. Gandy said, “I worry that things may look worse in the real world than they did under these very controlled conditions.”

 

 

storycrafter

Thanks for the info, Crushed.

I miss your Covid updates and thank you for doing them as long as you did. It's probably more localized now and can be very different from place to place.

Crushed

The Most important analysis  is deaths per million since March when vaccines reduced  death rates.  
Overalll USA death rate since March is 770 deaths per million
  
The four largest states  show a huge variation

New York  505 deaths per million

 California  558  Deaths per million 

Texas         1000 deaths per million 

Florida       1374 deaths per million 

Small states also show the variation
 Louisiana    1118   deaths per million
Alabama      883   deaths per million
Maryland     464   deaths per million

The reason is almost certainly clustering of anti vaxxers and mutual spread of disease.