An Important Week in Alzheimer's Disease Research

Lane Simonian

This week there were three important findings regarding Alzheimer's disease:

The first found that Alzheimer's disease is primarily caused by oxidative stress and that it potentially can be treated with a series of antioxidants.

The editor for this group concluded that: "I anticipate that the OS (oxidative stress) hypothesis will gain its rightful recognition sooner in AD research to guide drug development tbat will effectively reduce OS and preserve cognitive function," concludes Dr. Mandal.

https://www.news-medical.net/news/20240521/Understanding-the-role-of-oxidative-stress-in-Alzheimers-disease-pathogenesis.aspx

Specifically he confirmed a previous study in which depletion of the brain's master antioxidant precisely mapped the onset and progression of Alzheimer's disease.

https://atlasofscience.org/glutathione-a-molecular-whistleblower-for-alzheimers-disease/

The second study sought to answer the question as to why some inidividuals with misfolded amyloid and tau proteins did not develp Alzheimer's disease. The researchers found that they had high levels of the antioxidant metallothionein in their brains.

https://neurosciencenews.com/resilience-alzheimers-pathology-26111/

The third study found that amyloid and tau were only two of the many nitrated/insoluble proteins that contributed to Alzheimer's disease.

https://www.technologynetworks.com/neuroscience/news/protein-clumping-in-alzheimers-and-normal-aging-explored-in-new-study-386860

Among other things nitrated enzymes and transport systems inhibit the regeneration of neurons in the hippocampus and the production of acetylcholine which is needed for the retrieval of short-term memories.

Alzheimer's disease is primarily caused by oxidation and nitration. Certain treatments such as aromatherapy with antioxidant essential oils that can easily reach the hippocampus or plants that contain multiple antioxidants such as panax ginseng can either stabilize or slow the progression of the disease and lead to improvements in certain forms of cognition.

ButterflyWings

This really is HUGE. Thank you for posting it @Lane Simonian

SusanB-dil

Thanks, Lane.