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Any heterozygotes on Donanemab?

Leonard Shelby
Leonard Shelby Member Posts: 9
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Member
in I Am Living With Younger Onset Alzheimer's

Got my APOE results back and I am E3/E4. Waiting for my next appt with the NP to discuss next steps. I know that E4/E4 is pretty much a no go for Donanemab. E3/E4 is supposedly 50% less chance of ARIA, but still a risk. My Centiloid is 144. So, lots of existing plaques. Donanemab is for clearing those. Lecanemab is for stoping the formation of new ones. I am going to go with what the Doc says. But, curious if any of you with a high plaque burden that have started treatment had that discussion with your Doc, and which you eventually got on. Thank you.

Commonly Used Abbreviations


DH = Dear Husband
DW= Dear Wife, Darling Wife
LO = Loved One
ES = Early Stage
EO = Early Onset
FTD = Frontotemporal Dementia
VD = Vascular Dementia
MC = Memory Care
AL = Assisted Living
POA = Power of Attorney
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