Any experience with Rexulti?

Agree with above. I would ask specifically why he wants Rexulti and i would bet he won't have an answer for you—except that he's seen the ads or received drug detailing about the FDA indication also. I personally would increase the olanzapine or use a different drug like Seroquel or Risperdal—unless he has prior experience with those? i don't think the increased cost of Rexulti is worth it….

For what it's worth with this late reply, Rexulti has done wonders for my LO with mid-stage AD and is completely covered by her Medicaid/Medicare. She went from being psychotic, regularly severely agitated, and not eating or drinking, to - within ONE WEEK - becoming relaxed and happier than we'd seen her in years. She also regained her appetite and now we need to watch her weight. She takes it in combination with 30 mg of mirtazipine (Remeron). Alone, the Remeron did nothing or little for her that we could tell, but in combination with the recommended 2 mg of Rexulti, the combination has helped her tremendously. These are the only two meds she takes. It used to take us 1 - 2 hours to settle her into sleep with her tossing, turning, whimpering, and now she wants to go to her bed and falls asleep within minutes. She is also still connected and with us (not overly sedated, though sleepy after taking it in the eve). We first tried Seroquel but it immediately made her symptoms worse.

DW went on Rexulti about a year ago for severe agitation, she seems to peek in afternoons. After consulting w/our Geri psych we opted to dose 1 mg. each morning. DW responded positively, no side effects. She's on Medicare now, cost is covered through our local PACE program as I don't pay anything.

My DH started on Rexulti about 3 mos. ago. His psych Doc has plenty of samples. Because I questioned the cost. He said he would never prescribe it for someone on Medicare because of the cost. When I questioned Dr further about its efficacy, he stated that he has found a smoother reaction compared to Seroquel. His dose was increased to 2 mg. in PM or dinnertime. DH becomes agitated with me if I say something he doesn't like. But he has been doing that for 40 yrs, so I wouldn't expect that to change. He has been manifesting sundowning since he started Rexulti. Is that the progression of the disease or a side effect of the Rexulti. Who knows. The only way to know is by titrating him off the Rexulti but I don't feel he has had a long enough trial. Someone said they had good results when Remeron was added. He sees the Dr on Thursday so I will ask his opinion.

Here's some info on PACE programs.

PACE | Medicare

welcome Jeff. Thank you for the info. You have responded to an old post from 2024. You will get more replies and help others more by creating a new post. Click on the plus sign at the bottom of the page and put in a subject line. Copy and paste your post there. Glad you’re here but sorry for the reason. This community helped me more than anything.