Any Advice for Stopping MCI Progression

My husband started out with MCI many years ago. He did everything except the plant based diet and after two years there was some improvement based on testing in one area(can't remember which area) but when he was tested two years later there was significant decline. And it has been downhill ever since. He did a bunch of supplements too that were recommended by the Breadenson protocol. I think you may be able to slow it down in the short term but eventually it catches up.

My DH was diagnosed in 9/2023 with MCI and Alzheimer’s. His initial symptoms began end of 6/2022 after a brief mild Covid episode. His symptoms were anxiety and multiple somatic complaints that escalated by 12/2022 despite seeking treatment for these symptoms early on in itch his PCP and a geriatric psych md. His neuropsych testing revealed executive function was primary area of significant impact. He was started on aricept 10mg in 9/2023 followed by neurocognitive and external brain stimulation prescribed by a neuropsych who has an expertise in dementia/alzheimers. Retesting 2 years later 6/2025 revealed a 2 point lower standard deviation in his testing. His memory and ability to perform adls remain ok. It’s his behavioral changes of anxiety, obsessive compulsiveness, changes to willingness to eat and how much he’ll eat that is the biggest issue and most impactful to his function. Unfortunately he has 2 copies of the APOE4 gene which placed him at increased risk for Alzheimer’s and which also prevents him from trying any of the newer infusion meds due to much higher risk for brain bleeds or swelling. So despite trying to treat him aggressively including brain ha, sudoku puzzles, cognitive stimulation therapy once a week for 1 hr and music therapy once a week and 2 days of social adult daycare for dementia patients it is and will continue to progress unfortunately. It’s a horrible disease for both caregivers and those affected with it.