Just diagnosed with MCI and on Memantine 28mg - Need mental health help !

I visited a Nurse Practitioner in January 2024 who performed a quick cognitive assessment and recommended a detailed follow-up neuropsychological exam. In Feb 2024 I started on Aricept. My MCI diagnosis was in April 2024 and in June 2024 I started on Leqembi (that was the only FDA-approved monoclonal antibody treatment at that time, now Kisunla is a second option). I recently had my 44th dosing of Leqembi, all with no side effects. I had another quick cognitive assessment about a year after starting on Leqembi and scored the same, I took that as a success. In Dec 2025 I had a new AD blood test, which showed that I am now amyloid clear albeit with a small amount of tau (current research seems to indicate tau is a bigger concern with respect to cognitive decline compared to amyloid plaque).

I like to believe that nowadays, those diagnosed with AD have some hope for the future. Specifically, treatment with Leqembi or Kisunla showed slowing of cognitive decline for the overall populations in the respective Phase 3 clinical trials, while those with lower tau levels at the start of treatment often were able to maintain their cognitive levels without any decline. I like to hope that with Leqembi treatments, I will be able to retain sufficient cognitive capabilities until new breakthrough treatments become available in the next few years. This isn't simply wishful thinking, there are on-going Phase 3 clinical trials with anti-tau drugs. The Phase 2 trials with these drugs showed good performance at reducing tau levels in humans. The theory is that a combination of anti-amyloid drugs (i.e. Leqembi/Kisunla) with anti-tau drugs may permanently halt the progression of AD. There is actualy one on-going trial combining Leqembi with an anti-tau drug to test that theory. If not a combination of anti-amyloid & anti-tau drugs, there are literally hundreds of other drugs for AD now undergoing clinical trials.

I live one day at a time with a realistic hope for the future. Here in 2026, an AD diagnosis no longer means just getting your affairs in order and waiting for future cognitive decline. Nowadays, if you take proactive steps to manage your AD, you may live a long, dementia-free life, and die of other problems.

The Alzheimer's Association has some information about treatment options on their website at the link below. I recently watched an ALZ Talk (discussions about Alzheimer's sponsored by the Alzheimer's Association) regarding Leqembi & Kisunla. See the talk titled "ALZ Talks: Opening the Door to New Alzheimer's Treatment". I found the talk to be very helpful.