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Good review article M1 receptor targeting

allit
allit Member Posts: 100
10 Comments 5 Care Reactions 5 Insightfuls Reactions 5 Likes
Member
in I Am a Caregiver (General Topics)

I came across this good review article from 2022 when I was looking for things to help my wife who is experiencing adverse effects from donepezil and rivastigmine.
It’s a good review article of the progress being made to develop drugs that have less adverse effects. Doesn’t look like anything is coming on the market anytime soon. But, if they can refine this class then there is potential for using them even in the severe stages to improve outcomes.

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https://portlandpress.com/neuronalsignal/article/6/1/NS20210004/231109

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  • allit
    allit Member Posts: 100
    10 Comments 5 Care Reactions 5 Insightfuls Reactions 5 Likes
    Member

    One thing that’s frustrating, Vanderbilt University developed a compound VU319 but then licensed it to Acadia Pharmaceuticals and it seems like since then there’s been no word on it.

  • allit
    allit Member Posts: 100
    10 Comments 5 Care Reactions 5 Insightfuls Reactions 5 Likes
    Member

    An article on Vanderbilt U and compound VU319. Mentions the Alzheimer’s Association Part the Cloud program

    https://www.vumc.org/ccm/sites/default/files/VU319%20ARTICLE%20FROM%20VU.pdf

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