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From Michael Ellenbogen (via Lane): Alzheimer's Disease Drugs in Development 2023

Lane Simonian
Lane Simonian Member Posts: 352
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in I Am Living With Alzheimer's or Other Dementia

This report on Alzheimer's drugs under development comes out annually. I believe that certain antioxidants provide the best chance of treating the disease. I counted 5 out of 187 drugs/natural products that act as antioxidants.


https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12385

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  • Iris L.
    Iris L. Member Posts: 4,478
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    What are the 5 antioxidant products from this study?

  • Lane Simonian
    Lane Simonian Member Posts: 352
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    edited May 2023

    Beautiful, important question, Iris. I should have specified them in my originial post (I missed two of them while counting off the chart). They are:


    Phase 3 Clinical Trials

    Omega-3 (in fish oil and walnuts, for example),

    Hydralozine-hydrochloride (used to treat high blood pressure),

    Icosapent ethyl (a type of fish oil)


    Phase 2 Clinical Trials

    Edaravone (used to treat stroke and ALS)

    DHA (a type of Omega-3 found in fish oil)

    Flos Gossypii Flavonoids (derived from a flower of the same name)


    Phase 1 Clinical Trial

    CMS 121 (derivative of the flavanoid fisetin which can be found in strawberries among other fruits and vegetables)

    I just noticed that only Hydralozine-hydrochloride and Flos Gossypii Flavanoids are the only ones being studied for mild to moderate Alzheimer's disease. The others are earlier interventions.

  • Iris L.
    Iris L. Member Posts: 4,478
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    edited May 2023

    This is too complicated. The only ones I recognize are fish oil, walnut and strawberries, and a blood pressure medicine, which I am already eating and on. Flavanoids are in oranges. I have to keep things very simple for myself because my memory and cognition have been compromised. But thank you for responding, Lane.

    Iris

  • Lane Simonian
    Lane Simonian Member Posts: 352
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    All good choices, Iris.

  • inertia
    inertia Member Posts: 12
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    https://alzconnected.org/discussion/comment/173382#Comment_173382

    I agree it is not something a ad patient should not even attempt to read and understand that!

Commonly Used Abbreviations


DH = Dear Husband
DW= Dear Wife, Darling Wife
LO = Loved One
ES = Early Stage
EO = Early Onset
FTD = Frontotemporal Dementia
VD = Vascular Dementia
MC = Memory Care
AL = Assisted Living
POA = Power of Attorney
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